Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis.
Shang-Yu YangChi-Jung FangYu-Wen ChenWan-Ping ChenLi-Ya LeeChin-Chu ChenYen-You LinShan-Chi LiuChun-Hao TsaiWei-Chien HuangYang-Chang WuChih-Hsin TangPublished in: Nutrients (2022)
Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability. Hericium erinaceus is a large edible mushroom with several known medicinal functions. However, the therapeutic effects of H. erinaceus in OA are unknown. In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that H. erinaceus mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain. ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with H. erinaceus mycelium. In addition, H. erinaceus mycelium reduced the synthesis of proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in OA cartilage and synovium. H. erinaceus mycelium shows promise as a functional food in the treatment of OA.
Keyphrases
- knee osteoarthritis
- anterior cruciate ligament
- rheumatoid arthritis
- diabetic rats
- chronic pain
- multiple sclerosis
- physical activity
- drug induced
- total knee arthroplasty
- body mass index
- oxidative stress
- pain management
- combination therapy
- neuropathic pain
- bone mineral density
- body composition
- risk assessment
- mouse model
- spinal cord
- spinal cord injury
- endothelial cells
- climate change
- replacement therapy