Modifying loading during gait leads to biochemical changes in serum cartilage oligomeric matrix protein concentrations in a subgroup of individuals with anterior cruciate ligament reconstruction.
Cortney N Armitano-LagoAlyssa Evans-PickettHope Davis-WilsonAmanda MunschLara LongobardiHelen WillcocksonTodd A SchwartzJason R FranzBrian PietrosimonePublished in: Clinical rheumatology (2024)
These data suggest that manipulating lower limb loading in ACLR patients who habitually exhibit an acute increase in sCOMP following walking results in improved biochemical changes linked to cartilage health. Key Points • This study assesses the mechanistic link between lower limb load modification and joint tissue biochemistry at acute and delayed timepoints. • Real-time biofeedback provides a paradigm to experimentally assess the mechanistic link between loading and serum biomarkers. • Manipulating peak loading during gait resulted in a metabolic effect of lower sCOMP concentrations in a subgroup of ACLR individuals. • Peak loading modifications may provide an intervention strategy to mitigate the development of PTOA following ACLR.
Keyphrases
- lower limb
- liver failure
- healthcare
- anterior cruciate ligament reconstruction
- respiratory failure
- public health
- mental health
- drug induced
- intensive care unit
- electronic health record
- hepatitis b virus
- big data
- deep learning
- risk assessment
- cerebral palsy
- health information
- acute respiratory distress syndrome
- phase iii
- open label