Targeted gene panel analysis of Japanese patients with maturity-onset diabetes of the young-like diabetes mellitus: Roles of inactivating variants in the ABCC8 and insulin resistance genes.
Tohru YorifujiYoh WatanabeKana KitayamaYuki YamadaShinji HiguchiJun MoriMasaru KatoToru TakahashiTokuko OkudaTakane AoyamaPublished in: Journal of diabetes investigation (2022)
Causative genomic variants could be identified in at least 46.2% of clinically suspected MODY patients. ABCC8-MODY with inactivating variants could represent a distinct category of MODY. Genes of insulin resistance should be included in the sequencing panel for MODY.
Keyphrases
- copy number
- insulin resistance
- genome wide
- type diabetes
- end stage renal disease
- genome wide identification
- glycemic control
- adipose tissue
- metabolic syndrome
- newly diagnosed
- dna methylation
- ejection fraction
- chronic kidney disease
- cardiovascular disease
- polycystic ovary syndrome
- skeletal muscle
- prognostic factors
- cancer therapy
- pulmonary embolism
- drug delivery
- middle aged
- patient reported outcomes
- transcription factor