Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps.

Fadwa A ElsayedCarli M J TopsMaartje NielsenDina RuanoHans F A VasenHans MorreauFrederik J Hes J Tom van Wezel

Published in: Molecular genetics & genomic medicine (2019)

This study confirms the low frequency of causal variants in these genes in the predisposition for multiple colorectal polyps, and also establishes that these genes are a rare cause of the disease.

Keyphrases

copy number
genome wide
chronic rhinosinusitis
bioinformatics analysis
genome wide identification
gene expression
genome wide analysis
transcription factor