Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.

Maite E HouwingRowena L GrohssteinerMarjolein H G DremmenFerdows AtiqWichor M BramerAnne P J de PagterC Michel ZwaanTonya J H WhiteMeike W VernooijMarjon H Cnossen

Published in: BMC medicine (2020)

This systematic review and meta-analysis shows SCIs are common in patients with SCD. No clear risk factors for their development were identified. Larger, prospective and controlled clinical, neuropsychological and neuroimaging studies are needed to understand how SCD and SCIs affect cognition.

Keyphrases

ejection fraction
newly diagnosed
mild cognitive impairment
prognostic factors
multiple sclerosis
white matter
patient reported outcomes
blood brain barrier