Impact of thiopurine discontinuation at anti-tumour necrosis factor initiation in inflammatory bowel disease treatment: a nationwide Danish cohort study.
Sandra Bohn ThomsenRyan C UngaroKristine Højgaard AllinRahma ElmahdiGry Juul PoulsenMikael AnderssonJean Frederic ColombelTine JessPublished in: Alimentary pharmacology & therapeutics (2022)
In a nationwide cohort study of IBD patients, we observed that discontinuing thiopurines after anti-TNF initiation was associated with an increased risk of adverse outcomes, in particular an increase in hospitalizations. Further interventional studies exploring this common clinical scenario are required.