S-15 in combination of Akt inhibitor promotes the expansion of CD45RA-CCR7+ tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1+Tim-3+ cells as well as regulatory T cells.

Ben-Ling XuLong YuanGuangyu ChenTiepeng LiJinxue ZhouChengjuan ZhangPeng QinMusleh M MuthanaShengdian WangXuexiang DuQuanli Gao

Published in: Cancer cell international (2019)

Our study elucidates that IL-2/S-15/Akti expanded Tils and represent a viable source for the cellular therapy for patients with hepatocellular cancer.

Keyphrases

regulatory t cells
dendritic cells
induced apoptosis
signaling pathway
papillary thyroid
rheumatoid arthritis
cell cycle arrest
cell proliferation
squamous cell
squamous cell carcinoma
endoplasmic reticulum stress
oxidative stress
ankylosing spondylitis
disease activity
childhood cancer
interstitial lung disease