Assessment of inflammation with hematological parameters in patients with migraine and tension-type headache: a prospective study from a tertiary care center.
Halil Okay AlbayrakHande Gurbuz AytulukSehnaz BasaranSerkan YılmazPublished in: Pain management (2021)
Aim: To investigate the role of inflammatory markers in patients with an acute headache attack. Materials & methods: This prospective controlled observational study comprised 150 subjects (migraine with aura [MA] n = 51, migraine without aura [MO] n = 51, tension-type headache n = 48, healthy controls n = 80). White blood cells (WBC), neutrophil, lymphocyte and platelet counts, mean platelet volume, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were documented. Results: MA and MO constituted 14.2% of the admissions to the emergency department due to headaches. In addition, MA and MO had higher WBC and MO showed higher neutrophil count during the attacks than healthy control (p < 0.05). Conclusion: Although inflammatory parameters, including WBC and neutrophil counts, were high in headache patients, neutrophil-to-lymphocyte ratio did not show a significant rise. Clinical trial registration: NCT04891848.
Keyphrases
- peripheral blood
- emergency department
- clinical trial
- tertiary care
- end stage renal disease
- oxidative stress
- induced apoptosis
- newly diagnosed
- ejection fraction
- chronic kidney disease
- cell cycle arrest
- patient reported outcomes
- intensive care unit
- cell death
- drug induced
- signaling pathway
- double blind
- acute respiratory distress syndrome
- hepatitis b virus