Distinct Lymphocyte Immunophenotyping and Quantitative Anti-Interferon Gamma Autoantibodies in Taiwanese HIV-Negative Patients with Non-Tuberculous Mycobacterial Infections.
Wen-I LeeYao-Fan FangJing-Long HuangHuey-Ling YouMeng-Ying HsiehWan-Ting HuangChi-Jou LiangChen-Chen KangTing-Shu WuPublished in: Journal of clinical immunology (2023)
In patients with suspected adult-onset immunodeficiency syndrome, two thirds (20/31) were recognized as having significantly inhibitory AutoAbs-IFN-γ with higher antibody-enhancing transitional, CD19 + CD21-low and plasmablast B cells; as well as higher effector memory, senescent CD8 + CD57 + and Th17 cells, but lower naïve T and Treg cells in contrast to those with negligible AutoAbs-IFN-γ. Such immunophenotyping disturbances might correlate with the presence of AutoAbs-IFN-γ. However, the mutual mechanisms need to be further clarified.
Keyphrases
- dendritic cells
- induced apoptosis
- cell cycle arrest
- immune response
- endoplasmic reticulum stress
- hiv infected
- antiretroviral therapy
- magnetic resonance
- high resolution
- flow cytometry
- mycobacterium tuberculosis
- human immunodeficiency virus
- regulatory t cells
- cell death
- computed tomography
- working memory
- cell proliferation
- pi k akt
- mass spectrometry