Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells.
Xiao-Fei YangShu-Yan ZhouCe WangWei HuangNing LiFei HeFu-Rong LiPublished in: Stem cell research & therapy (2020)
LSD1 regulated histone methylation and acetylation in promoter regions of pluripotent or endodermal genes. Our results suggest a highly efficient approach to producing IPCs from hiPSCs.
Keyphrases
- induced pluripotent stem cells
- highly efficient
- dna methylation
- genome wide
- induced apoptosis
- transcription factor
- type diabetes
- cell cycle arrest
- gene expression
- endothelial cells
- endoplasmic reticulum stress
- cell death
- oxidative stress
- signaling pathway
- glycemic control
- bioinformatics analysis
- pi k akt
- insulin resistance
- skeletal muscle
- cell proliferation
- genome wide analysis