Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies.

Hsiao P J VoonLinda HiiAndrew GarvieMaheshi UdugamaBrian KrugCaterina RussoAnderly C ChüehRoger J DalyAlison MoreyToby D M BellStephen J TurnerJoseph RosenbluhPaul DanielRon FiresteinJeffrey R MannPhilippe CollasNada JabadoLee H Wong

Published in: Genome biology (2023)

We identify PML as a contributor to oncogenesis in a subset of gliomas and show that targeting PML bodies is effective in treating these H3.3-mutated pediatric gliomas.

Keyphrases

high grade
dna methylation
young adults