Dapagliflozin improves pancreatic islet function by attenuating microvascular endothelial dysfunction in type 2 diabetes.

Yunyi LeJin YangFei LiYafei JiangTianjiao WeiDandan WangKangli WangXiaona CuiXiafang LinKun YangTianpei Hong Rui Wei

Published in: Diabetes/metabolism research and reviews (2022)

Dapagliflozin restores islet vascularisation and attenuates the inflammation of IMECs in type 2 diabetic mice. The dapagliflozin-induced improvement of ß cell function is at least partially accounted for by its beneficial effects on IMECs in a PI3K/Akt-mTOR-dependent manner.

Keyphrases

type diabetes
oxidative stress
diabetic rats
high glucose
cardiovascular disease
glycemic control
insulin resistance
drug induced
skeletal muscle