This study highlights the crucial role of microglial GLP1R in epilepsy pathophysiology. GLP1R downregulation contributes to microglial- and astrocyte-mediated neurotoxicity, exacerbating neuronal death and seizures. Activation of GLP1R with Ex-4 has emerged as a promising therapeutic strategy to reduce neuroinflammation, protect neuronal cells, and control seizures in epilepsy. This study provides a foundation for developing novel antiepileptic therapies targeting microglial GLP1R, with the potential to improve outcomes in patients with epilepsy.
Keyphrases
- lipopolysaccharide induced
- lps induced
- inflammatory response
- cerebral ischemia
- neuropathic pain
- cell cycle arrest
- traumatic brain injury
- temporal lobe epilepsy
- cell death
- signaling pathway
- metabolic syndrome
- cancer therapy
- endoplasmic reticulum stress
- cognitive impairment
- risk assessment
- adipose tissue
- insulin resistance