Aging-related alterations in mechanistic target of rapamycin signaling promote platelet hyperreactivity and thrombosis.

Irina PortierBhanu Kanth ManneYasuhiro KosakaNeal D TolleyFrederik DenormeÖzgün BaburAshok P ReddyPhillip A WilmarthJoseph E AslanAndrew S WeyrichMatthew T RondinaRobert A Campbell

Published in: Journal of thrombosis and haemostasis : JTH (2024)

Aging-related changes in mTOR phosphorylation enhance Rac1 and p38 activation to enhance thromboxane generation, platelet hyperactivity, and thrombosis.

Keyphrases

pulmonary embolism