Impact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository.

Toshie SaitoYue WeiLi WenChaitanya SrinivasanBenjamin O WolthersCheng-Yu TsaiMarian H HarrisKristen StevensonCraig ByersdorferJudy-April OparajiChristian FernandezAmitava MukherjeeMaisam Abu-El-HaijaSameer AgnihotriKjeld SchmiegelowMegan R ShowalterPaul W FogleScott McCullochKevin ContrepoisLewis B SilvermanYing DingSohail Z Husain

Published in: Metabolomics : Official journal of the Metabolomic Society (2021)

Metabolomic profiling in ALL patients revealed a large number of alterations following induction chemotherapy. In particular, lipid metabolism was substantially altered. The changes in metabolites and complex lipids following induction therapy could provide insight into the adverse events experienced by ALL patients.

Keyphrases

end stage renal disease
acute lymphoblastic leukemia
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
single cell
patient reported outcomes
acute myeloid leukemia
patient reported
cell therapy
allogeneic hematopoietic stem cell transplantation
replacement therapy