Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis.

Marina Sicignano Ricardo I Rodríguez Vito CapaccioFabio BorelloRafael Cano Francesco De Riccardis Luca Bernardi Sergio Diaz-Tendero Giorgio Della Sala José Alemán

Published in: Organic & biomolecular chemistry (2020)

The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.

Keyphrases

density functional theory
electron transfer
molecular dynamics
molecular dynamics simulations
visible light
solar cells
solid state