Non-invasive Imaging of Antisense Oligonucleotides in the Brain via In Vivo Click Chemistry.

Brendon E CookJonathan ArchboldKhaled NasrSara GirmayStanley I GoldsteinPei LiSivaraman DandapaniNathan E GenungSac-Pham TangStuart McCluskyChristophe PlissonMegan E AfetianChrissa A DwyerMichael FazioWilliam J DruryFrank RigoLaurent MartarelloMaciej Kaliszczak

Published in: Molecular imaging and biology (2022)

A CNS-penetrant radioligand for pretargeted imaging was successfully demonstrated in a proof-of-concept study in rats, laying the groundwork for further optimization.

Keyphrases

high resolution
white matter
nucleic acid
mass spectrometry
drug discovery
brain injury