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Exploring microsatellite instability in patients with advanced hepatocellular carcinoma and its tumor microenvironment.

Shohei MukaiHiroaki KanzakiSadahisa OgasawaraTakamasa IshinoKeita OgawaMiyuki NakagawaKisako FujiwaraHidemi UnozawaTerunao IwanagaTakafumi SakumaNaoto FujitaKeisuke KorokiKazufumi KobayashiNaoya KanogawaSoichiro KiyonoMasato NakamuraTakayuki KondoTomoko SaitoRyo NakagawaEiichiro SuzukiYoshihiko OokaRyosuke MuroyamaShingo NakamotoAkinobu TawadaTetsuhiro ChibaMakoto AraiJun KatoManayu ShiinaMasayuki OtaJun-Ichiro IkedaYuichi TakiguchiMasayuki OhtsukaNaoya Kato
Published in: JGH open : an open access journal of gastroenterology and hepatology (2021)
We identified a very small number of MSI-H cases in HCC using one tumor biopsy sample for each patient with advanced HCC. In addition, epigenetic aberrations possibly lead to MSI-H in HCC patients. Since different HCC clones might coexist in the liver, sampling from multiple tumors should be considered to clarify the true proportion of MSI-H in HCC and to analyze tumor microenvironments.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • chronic kidney disease
  • newly diagnosed
  • gene expression
  • prognostic factors
  • peritoneal dialysis
  • copy number
  • patient reported
  • genetic diversity