Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns.
Joycilene da Silva BarbosaGdayllon Cavalcante MenesesLuan Rebouças CasteloGeraldo Bezerra da Silva JúniorAlice Maria Costa MartinsElizabeth de Francesco DaherTiago Lima SampaioAmanda de Oliveira GomesSuzzy Maria Carvalho DantasArthur da Silva RebouçasPaula Roberta de LimaNicole Coelho LopesMateus Edson da SilvaMac Dionys Rodrigues da CostaAna Amelia Reis JereissatiVictoria Queiroz RamosRosângela Pinheiro Gonçalves MachadoRomélia Pinheiro Gonçalves LemesPublished in: Biomarkers in medicine (2024)
Aim: To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay. Methods: Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1. Results: Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio: 1.052; 95% CI: 1.012-1.093; p = 0.01). Conclusion: uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.