Occult Colonic Perforation in a Patient With Coronavirus Disease 2019 After Interleukin-6 Receptor Antagonist Therapy.

Kristin E SchwabSepehr HamidiAugustine ChungRaymond J LimNegar KhanlouDaniel HoestereyCamelia DumitrasOladunni B AdeyigaMichelle Phan-TangTisha S WangRajan SaggarJeffrey GoldsteinJohn A BelperioSteven M DubinettJocelyn T KimRamin Salehi-Rad

Published in: Open forum infectious diseases (2020)

These data and absence of known risk factors for spontaneous colonic perforation implicate IL-6Ra therapy as the potential mediator of colonic injury in this case. Furthermore, this report provides the first in situ visual evidence of the virus in the colon of a patient presenting with colonic perforation adding to growing evidence that intact infectious virus can be present in the stool.

Keyphrases

ulcerative colitis
case report
coronavirus disease
rheumatoid arthritis
electronic health record
machine learning
risk assessment
big data
smoking cessation