Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2-mediated autophagy.

Lang FangJialun LvZhe XuanBowen LiZheng LiZhongyuan HeFengyuan LiJianghao XuSen WangYiwen XiaTianlu JiangLu ZhangLinjun WangDiancai ZhangHao XuLi YangZe-Kuan XuWeizhi Wang

Published in: Clinical and translational medicine (2022)

Our results reveal that circCPM has a crucial role in regulating GC autophagy and 5-FU resistance by targeting PRKAA2. It may function as a new theory basis for assessing the curative effect of GC and reversing 5-FU chemoresistance.

Keyphrases

signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
gas chromatography
genome wide
single cell
cancer stem cells
rectal cancer
prognostic factors
mass spectrometry
dna methylation
high resolution
solid phase extraction