Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2 H -pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones.

Nicolai A Aksenov Dmitrii A Aksenov Igor A Kurenkov Alexander V AksenovAnton A SkomorokhovLidiya A Prityko Michael Rubin

Published in: RSC advances (2021)

A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2 H -pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared via the previously known protocols, as 2-aminofuran derivatives were produced instead.

Keyphrases

structure activity relationship