Changes in the Vα7.2+ CD161++ MAIT cell compartment in early pregnancy are associated with preterm birth in HIV-positive women.
Krithi RaviChristina Y S ChanCharlene AkotoWei ZhangManu VatishShane A NorrisPaul KlenermanJoris HemelaarPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)
Interactions between HIV-related and pregnancy-related changes in MAIT cell subsets and distribution may lead to imbalances in peripheral MAIT cell subsets in early pregnancy. This may contribute to the increased risk of PTB in HIV+ patients by altering the overall functionality of the peripheral MAIT cell compartment.
Keyphrases
- hiv positive
- preterm birth
- antiretroviral therapy
- single cell
- men who have sex with men
- cell therapy
- human immunodeficiency virus
- hiv infected
- south africa
- end stage renal disease
- hepatitis c virus
- ejection fraction
- chronic kidney disease
- type diabetes
- newly diagnosed
- peripheral blood
- prognostic factors
- peritoneal dialysis
- metabolic syndrome
- adipose tissue
- mesenchymal stem cells
- insulin resistance
- pregnancy outcomes
- low birth weight
- gestational age