Fusobacterium Detected in Barrett's Esophagus and Esophageal Adenocarcinoma Tissues.

We examined Fusobacterium nucreatum ( F. nucleatum ) and whole Fusobacterium species ( Pan-fusobacterium ) in non-neoplastic Barrett's esophagus (BE) from patients without cancer ( n  = 67; N group), with esophageal adenocarcinoma (EAC) ( n  = 27) and EAC tissue ( n  = 22). F. nucleatum was only detectable in 22.7% of EAC tissue. Pan-fusobacterium was enriched in EAC tissue and associated with aggressive clinicopathological features. Amount of Pan-fusobacterium in non-neoplastic BE was correlated with presence of hital hernia and telomere shortening. The result suggested potential association of Fusobacterium species in EAC and BE, featuring clinicpathological and molecular features.