High Prevalence of Unconfirmed Positive HIV PCR Test Results among African Infants with HIV Exposure in the International epidemiology Databases to Evaluate AIDS (IeDEA) Consortium.
James G CarlucciThomas HuntingtonKarl-Günter TechnauMarcel YotebiengValériane LeroyKim AndersonMadeleine Amorissani-FolquetKara Wools-KaloustianAndrew EdmondsPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
In a large, multi-regional cohort of African infants with HIV exposure, 44% of those with a positive HIV PCR lacked a confirmatory positive test. Efforts are needed to ensure high-fidelity implementation of HIV testing algorithms, so that all positive results are confirmed thereby reducing the risk of potentially false-positive results.