Login / Signup

Membrane protein biogenesis by the EMC.

Sara AlviraRobin Adam CoreyIan CollinsonKarin Römisch
Published in: The EMBO journal (2020)
The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo-EM structures, and a third model based on partial high- and low-resolution structures, suggest how this is accomplished.
Keyphrases
  • endoplasmic reticulum
  • high resolution
  • high throughput
  • genome wide
  • single molecule
  • binding protein
  • amino acid
  • gene expression
  • mass spectrometry
  • dna methylation
  • small molecule
  • estrogen receptor