808 nm-Light-Excited Near-Infrared Luminescent Lanthanide Metal-Organic Frameworks for Highly Sensitive Physiological Temperature Sensing.

Ongoing demand for accurate self-calibrated noninvasive thermometers for micro-/nano-scale applications, particular biomedical diagnosis, is driving the development of temperature sensors. Here a new type of lanthanide metal-organic framework having near-infrared absorption and near-infrared emission features is presented, and it is based on efficient Nd3+ -to-Yb3+ energy transfer in 808 nm photoexcitation. The results show that the ratiometric parameter of Nd0.5 Yb0.5 TPTC (TPTC= 1,1':4',1''-terphenyl]-3,3'',5,5''-tetracarboxylic acid) can deliver good exponential-type luminescence response to temperature in the physiological regime (293-328 K) with high relative sensitivity and accurate temperature resolution, as well as good biocompatibility and chemical stability. Such lanthanide-based materials are especially useful in biomedical applications.