Complement receptor 1 (CR1, CD35) association with susceptibility to leprosy.

Gabriela Canalli KretzschmarLuana Caroline OliveiraRenato Mitsunori NisiharaThirumalaisamy P VelavanSérvio Túlio StinghenEwalda R S StahlkeMaria Luiza Petzl-ErlerIara José T de Messias-ReasonAngelica Beate Winter Boldt

Published in: PLoS neglected tropical diseases (2018)

The results lead us to suggest a regulatory role for CR1 polymorphisms on mRNA and sCR1 levels, with haplotype-specific effects increasing susceptibility to leprosy, probably by enhancing parasite phagocytosis and inflammation.

Keyphrases

oxidative stress
transcription factor
binding protein
plasmodium falciparum
toxoplasma gondii
trypanosoma cruzi