Ruthenium(II)-Catalyzed Sterically Hindered C-H Acyloxylation to Synthesize Biaryl Isoquinoline Derivatives via Peresters.

A novel C-H acyloxylation method of 1-(1-naphthalen-1-yl)isoquinoline derivatives with peresters in the presence of [Ru( p -cymene)Cl 2 ] 2 has been developed. The combination of ruthenium(II), AgBF 4 , CoI 2 , and 2,2,6,6-tetramethyl-1-piperidinyloxy is found to be an effective catalytic system to provide various biaryl compounds in satisfactory yields within minutes. Notably, steric hindrance is a very important determinant of the reaction.