Palladium-Catalyzed Tandem Carbocyclization and Hetroarylation for the Synthesis of 2-(Trifluoromethyl)indenylmethyleneindoles.

Tao ZhangFan Chen Xiao-Hong ZhangPeng-Cheng QianXing-Guo Zhang

Published in: The Journal of organic chemistry (2018)

A palladium-catalyzed tandem cyclization and cross-coupling reaction of o-(2-chlorovinyl)alkynylbenzenes with indoles/pyrroles is developed. The process proceeds via intramolecular carbocyclization and subsequent hetroarylation to afford previously unknown trifluoromethyl-containing indenylmethyleneindoles, which are potentially useful in drug design.

Keyphrases

adverse drug
emergency department
energy transfer
drug induced