Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity.
Yiwen ZhangHongrong HuWeiwei LiuShu-Mei YanYuzhuang LiLikai TanYingshi ChenJun LiuZhilin PengYaochang YuanWenjing HuangFei YuXin HeBo LiHui ZhangPublished in: Journal for immunotherapy of cancer (2021)
Our results revealed that robust signaling of amino acids by RagD and downstream mTORC1 signaling were crucial for T-cell receptor-initiated antitumor immunity. The characterization the role of RagD and LEU in nutrient mTORC1 signaling in TILs might suggest potential therapeutic strategies based on the manipulation of RagD and its upstream pathway.
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