Genome-wide polygenic risk score, cardiometabolic risk factors, and type 2 diabetes mellitus in the Chinese population.

Ninghao HuangWendi XiaoJun LvCanqing YuYu GuoPei PeiLing YangIona Y MillwoodRobin G WaltersYiping ChenHuaidong DuDaniel AveryTingting OuJunshi ChenZhengming ChenTao HuangLiming Linull null

Published in: Obesity (Silver Spring, Md.) (2023)

This study identified an ideally fitting PRS model for identifying and predicting the risk of T2D suitable for the Chinese population. The quantified proportional structure of genetic risk factors, cardiometabolic risk factors, and their interaction was detected, which elucidated the critical effect of genetic factors.

Keyphrases

risk factors
genome wide
dna methylation
copy number
cardiovascular disease
weight loss