High serum gamma-glutamyltransferase level after hepatitis C virus elimination is a risk factor for the development of hepatocellular carcinoma.

Miyako MurakawaMina NakagawaHisaaki NishimuraShun KanekoMasato MiyoshiFukiko Kawai-KitahataSayuri NittaJun TsuchiyaTaro ShimizuKeiya WatakabeTomohiro MochidaKento InadaYasuhiro IizukaHideki SakaiYuki SakuraiAyako SatoSeishin AzumaTakahiro KawamuraChiaki MaeyashikiMasayuki KurosakiFumihiko KusanoHideki WatanabeHitoshi KurataYuko KarakamaTakeo FujiwaraYuki NagataToshihiro TanakaSei KakinumaRyuichi OkamotoYasuhiro Asahina

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2024)

High GGT levels at SVR were associated with HCC development after accounting for alcohol consumption and diabetes. GGT levels are influenced by genetic predisposition and may reflect mitochondrial dysfunction after HCV eradication.

Keyphrases

hepatitis c virus
alcohol consumption
human immunodeficiency virus
type diabetes
cardiovascular disease
genome wide
glycemic control
copy number
skeletal muscle
helicobacter pylori
insulin resistance