Intra-Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study.
Jean W LiewMohammed JarrayaAli GuermaziJohn LynchDavid T FelsonMichael NevittCora E LewisJames TornerFrank W RoemerMichel D CremaNa WangFabio BecceGabriela V RabasaTristan PascartTuhina NeogiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
CT-detected IA mineralization in the cartilage was associated with higher risk of MRI cartilage worsening in the same compartment and subregion over two years. These findings suggest potential localized, tissue-specific effects of IA mineralization on cartilage pathology in knee OA.
Keyphrases
- knee osteoarthritis
- extracellular matrix
- total knee arthroplasty
- contrast enhanced
- magnetic resonance imaging
- computed tomography
- rheumatoid arthritis
- oxidative stress
- clinical trial
- risk assessment
- anterior cruciate ligament
- anterior cruciate ligament reconstruction
- diffusion weighted imaging
- pet ct
- electron microscopy