Abundance and Associated Variations of Cytochrome P450 Drug-Metabolizing Enzymes in the Liver of East Asian Adults: A Meta-Analysis.

Xiao-Xiao AnYichao YuGuo-Fu LiGuo Yu

Published in: European journal of drug metabolism and pharmacokinetics (2021)

The current meta-analysis shows that the abundance levels of CYP enzymes appear to vary greatly among different East Asian individuals who have similar ethnic backgrounds and food habits. The pooled data of CYP abundance can be used as preliminary reference values along with the associated variations for the projections of pharmacokinetics through physiologically based pharmacokinetic (PBPK) approaches.

Keyphrases

antibiotic resistance genes
systematic review
microbial community
meta analyses
electronic health record
machine learning
risk assessment
climate change
adverse drug
data analysis