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Interaction phenomena between a cuff of an artificial urinary sphincter and a urethral phantom.

Arturo Nicola NataliEmanuele Luigi CarnielChiara Giulia Fontanella
Published in: Artificial organs (2019)
Male urinary incontinence is highly prevalent, leading to a miserable quality of life. The artificial urinary sphincter (AUS) is the device that closely simulates the function of the biological urinary sphincter. The precise evaluation of occlusion mechanisms and of interaction phenomena occurring between AUS cuff and urethral duct is fundamental for more reliable design. The action induced in the interaction with urethral duct under a specific pressure depends on its constitutive material and structural characteristics. The methods of experimental and computational bioengineering are exploited to investigate mechanical functionality of the coupled system, as AUS and urethral duct. Experimental tests are developed to investigate the response when the AUS is inflated around a urethral phantom. Numerical model of the cuff is developed mimicking the experimental tests for the validation. Subsequently, numerical models are exploited to interpret the interaction of the cuff with urethral phantoms considering the influence of urethral size and of tissues mechanical behavior, mimicking healthy and degraded configurations. The investigation provides useful information on the behavior of AUS cuff with urethral duct evaluating the action induced and represents a support for planning an extension of experimental tests on animal and human urethral samples.
Keyphrases
  • urinary incontinence
  • endothelial cells
  • healthcare
  • high glucose
  • gene expression
  • diabetic rats
  • computed tomography
  • magnetic resonance
  • oxidative stress