Whole-exome sequencing reveals novel vacuolar ATPase genes' variants and variants in genes involved in lysosomal biology and autophagosomal formation in oral granular cell tumors.

Josiane Alves França Tenzin Gayden Eric Bareke Jean Nunes Dos Santos Sílvia Ferreira de Sousa Luciana Bastos-RodriguesJacek MajewskiNada Jabado Hélder Antônio Rebelo Pontes Carolina Cavaliéri Gomes

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)

Although the mechanisms involved in oral GCT initiation and progression remain unclear, our results suggest that oral GCTs have V-ATPase variants similarly to GCTs from other tissues/organs, and additionally show variants in lysosomes/endosomes/autophagosomal genes.

Keyphrases

copy number
genome wide
gene expression
single cell
cell therapy
stem cells
bioinformatics analysis