White matter alterations in early Parkinson's disease: role of motor symptom lateralization.
Laura PelizzariSonia Di TellaMaria M LaganàNiels BergslandFederica RossettoRaffaello NemniFrancesca BaglioPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2019)
WM integrity was found to be significantly altered in RPD but not in LPD, suggesting that LPD profile may be associated to more favorable prognosis. Since clinical laterality onset may affect the extent of WM integrity changes, it should be taken into account in neuroimaging studies investigating PD.