Activated low-density granulocytes in peripheral and intervillous blood and neutrophil inflammation in placentas from SLE pregnancies.

Marit StockfeltGunilla LarssonHanna EngströmHenri PuttonenHenrik ZetterbergKaj BlennowChristopher SjöwallHelena StrevensAndreas JönsenAnders A BengtssonMaria Majczuk SennströmAgneta ZickertElisabet SvenungssonIva GunnarssonEstelle TrysbergBo JacobssonAnna-Karin Hultgård EkwallKarin ChristensonJohan BylundMattias N D SvenssonAnna-Carin Lundell

Published in: Lupus science & medicine (2021)

In women with SLE, locally produced chemokines in the placenta are increased and may attract and activate neutrophils. This in turn could contribute to placental inflammation and dysfunction and increased risk of placenta-related pregnancy complications.

Keyphrases

oxidative stress
systemic lupus erythematosus
preterm birth
disease activity
pregnancy outcomes
fluorescent probe
sensitive detection
pregnant women