Selective Metalations of 1,4-Dithiins and Condensed Analogues Using TMP-Magnesium and -Zinc Bases.

Alicia Castelló-MicóJulia NafeKosuke HigashidaKonstantin KaraghiosoffMarc GingrasPaul Knochel

Published in: Organic letters (2016)

TMPMgCl·LiCl and TMPZnCl·LiCl allow facile magnesiation and zincation, respectively, of the 1,4-dithiin scaffold, producing polyfunctionalized 1,4-dithiins. A subsequent metalation of these S-heterocycles can also be achieved with the same TMP bases, leading to 2,3-disubstituted-1,4-dithiins. The Mg- and Zn-TMP bases allow as well the successful metalation of 1,4,5,8-tetrathianaphthalene and 1,4,5,6,9,10-hexathiaanthracene.

Keyphrases

heavy metals
molecular docking
reduced graphene oxide
risk assessment
tissue engineering
oxide nanoparticles