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Formation of Catalytic Hotspots in ATP-Templated Assemblies.

Krishnendu DasHaridas KarRui ChenIlaria FortunatiCamilla FerrantePaolo ScriminLuca GabrielliLeonard J Prins
Published in: Journal of the American Chemical Society (2022)
The self-assembly of surfactant-based structures that rely for their formation on the combination of a thermodynamically controlled and a dissipative pathway is described. Adenosine triphosphate (ATP) acts as a high-affinity template and triggers assembly formation at low surfactant concentrations. The presence of these assemblies creates the conditions for the activation of a dissipative self-assembly process by a weak-affinity substrate. The substrate-induced recruitment of additional surfactants leads to the spontaneous formation of catalytic hotspots in the ATP-stabilized assemblies that cleave the substrate. As a result of the two self-assembly processes, catalysis can be observed at a surfactant concentration at which low catalytic activity is observed in the absence of ATP.
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