Hyper-Methylated Hub Genes of T-Cell Receptor Signaling Predict a Poor Clinical Outcome in Lung Adenocarcinoma.

Zixin HuChongxiang XueJiabin ZhengXingyu LuJia LiHuijing DongYixuan YuXu ZhangKexin TanHuijuan Cui

Published in: Journal of oncology (2022)

This study identifies hyper-methylation and concurrent repression of CD247, LCK, PSTPIP1 as immune negative indicators and risk factors for prognosis in LUAD. Moreover, EGFR/SRGN axis may participate in immune modification to influence ICIs response and clinical outcome in LUAD.

Keyphrases

genome wide
small cell lung cancer
dna methylation
bioinformatics analysis
epidermal growth factor receptor
tyrosine kinase