Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells.

Shuang LiJun-Kun ZhanYan-Jiao WangXiao LinJia-Yu ZhongYi WangPan TanJie-Yu HeXing-Jun CuiYi-Yin ChenWu HuangYou-Shuo Liu

Published in: Cell & bioscience (2019)

Our data indicate an intracellular role for VCAN in VSMCs. VCAN participates in hyperglycemia-induced calcification/senescence via modulation of mitochondrial function in VSMCs.

Keyphrases

vascular smooth muscle cells
endothelial cells
high glucose
diabetic rats
angiotensin ii
chronic kidney disease
oxidative stress
dna damage
mesenchymal stem cells
vascular endothelial growth factor
stem cells
electronic health record
stress induced
big data
data analysis