In Vitro Ciclopirox Glucuronidation in Liver Microsomes from Humans and Various Experimental Animals.

Wenjing LiYufan XueFeng ZhangLing XiaoZhu HuangWenjuan LiLiangliang ZhuGuangbo Ge

Published in: European journal of drug metabolism and pharmacokinetics (2024)

Ciclopirox glucuronidation displays remarkable species differences with UGT1A9 as a dominant contributor in humans. It is suggested that the pharmacological or toxicological effects of ciclopirox may be UGT1A9 and species dependent.

Keyphrases

genetic diversity