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Exploring a De Novo Route to Bradyrhizose: Synthesis and Isomeric Equilibrium of Bradyrhizose Diastereomers ≠ .

Vitor L S CunhaGeorge Augustine O'DohertyTodd L Lowary
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
A de novo asymmetric strategy for the synthesis of d-bradyrhizose diastereomers from an achiral ketoenolester precursor is described. Key transformations used in the stereodivergent approach include two Noyori asymmetric reductions, an Achmatowicz rearrangement, diastereoselective alkene oxidations, and the first example of a palladium(0)-catalyzed glycosylation of a vinylogous pyranone. The isomeric composition of the bicyclic reducing sugars obtained was analyzed and their behaviour was compared to the natural product, revealing key stereocentres that impact the overall distribution.
Keyphrases
  • molecular dynamics
  • solid state
  • molecular dynamics simulations
  • aqueous solution