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Rapid response to emerging biomedical challenges and threats.

Marek GrabowskiJoanna M MacnarMarcin CymborowskiDavid R CooperIvan G ShabalinMirosław GilskiDariusz BrzezinskiMarcin KowielZbigniew DauterBernhard RuppAlexander WlodawerMariusz JaskolskiWladek Minor
Published in: IUCrJ (2021)
As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have been deposited in the Protein Data Bank within less than a year. The avalanche of new structural data has given rise to multiple resources dedicated to assessing the correctness and quality of structural data and models. Here, an approach to evaluate the massive amounts of such data using the resource https://covid19.bioreproducibility.org is described, which offers a template that could be used in large-scale initiatives undertaken in response to future biomedical crises. Broader use of the described methodology could considerably curtail information noise and significantly improve the reproducibility of biomedical research.
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