Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials.
Jennifer Susan LeesPeter HanlonElaine W ButterlySarah H WildFrances S MairRod S TaylorBruce GuthrieKatie GilliesSofia DiasNicky J WeltonDavid A McAllisterPublished in: BMJ medicine (2022)
Increased comorbidity count, irrespective of age and sex, is associated with a modest increased odds of participant attrition. The benefit of increased generalisability of including participants with multimorbidity seems likely to outweigh the disadvantages of increased attrition.