Hippocampal avoidance prophylactic cranial irradiation (HA-PCI) for small cell lung cancer reduces hippocampal atrophy compared to conventional PCI.
Michiel B de RuiterPaul F C GrootSabine DeprezPim PullensStefan SunaertDirk de RuysscherSanne B SchagenJosé BelderbosPublished in: Neuro-oncology (2022)
HA-PCI reduces hippocampal atrophy at 4 and 12 months compared to regular PCI. Both types of radiotherapy are associated with considerable brain injury. We did not find evidence for excessive brain injury after HA-PCI relative to PCI. Hippocampal atrophy was not associated with memory decline in this population as measured with HVLT-R. The usefulness of HA-PCI is still subject to debate.
Keyphrases
- brain injury
- percutaneous coronary intervention
- coronary artery disease
- acute myocardial infarction
- cerebral ischemia
- acute coronary syndrome
- antiplatelet therapy
- st elevation myocardial infarction
- subarachnoid hemorrhage
- st segment elevation myocardial infarction
- small cell lung cancer
- atrial fibrillation
- coronary artery bypass grafting
- early stage
- blood brain barrier
- left ventricular
- weight gain
- physical activity