Login / Signup

Hippocampal avoidance prophylactic cranial irradiation (HA-PCI) for small cell lung cancer reduces hippocampal atrophy compared to conventional PCI.

Michiel B de RuiterPaul F C GrootSabine DeprezPim PullensStefan SunaertDirk de RuysscherSanne B SchagenJosé Belderbos
Published in: Neuro-oncology (2022)
HA-PCI reduces hippocampal atrophy at 4 and 12 months compared to regular PCI. Both types of radiotherapy are associated with considerable brain injury. We did not find evidence for excessive brain injury after HA-PCI relative to PCI. Hippocampal atrophy was not associated with memory decline in this population as measured with HVLT-R. The usefulness of HA-PCI is still subject to debate.
Keyphrases