Serum neurofilament light chain reflects inflammation-driven neurodegeneration and predicts delayed brain volume loss in early stage of multiple sclerosis.
Barbora SrpovaTomas UherTereza HrnciarovaChristian BarroMichaela AndelovaZuzanna MichalakManuela VaneckovaJan KrasenskyLibuse NoskovaEva Kubala HavrdovaJens KuhleDana HorakovaPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2020)
sNfL is associated with ongoing neuroinflammation and predictive of future neurodegeneration in early MS.
Keyphrases
- multiple sclerosis
- early stage
- white matter
- oxidative stress
- cerebral ischemia
- resting state
- traumatic brain injury
- current status
- cerebrospinal fluid
- mass spectrometry
- lipopolysaccharide induced
- cognitive impairment
- lps induced
- sentinel lymph node
- functional connectivity
- squamous cell carcinoma
- lymph node
- blood brain barrier
- radiation therapy