CXCR4/ACKR3/CXCL12 axis in the lymphatic metastasis of vulvar squamous cell carcinoma.

Natalia Rusetska Kamil Kowalski Kamil Zalewski Sebastian Zięba Mariusz Bidzinski Krzysztof Goryca Beata U Kotowicz Malgorzata FuksiewiczJanusz KopczynskiElwira Bakuła-Zalewska Artur Kowalik Magdalena Kowalewska

Published in: Journal of clinical pathology (2021)

It appears that during progression and lymphatic spread of VSCC, the CXCR4/ACKR3/CXCL12 axis is activated. Moreover, our data suggest that CXCR4 antagonists merit further attention as a possible therapeutic option in patients with VSCC.

Keyphrases

squamous cell carcinoma
cell migration
lymph node
working memory
electronic health record
big data
lymph node metastasis
locally advanced
radiation therapy
early stage